Invention Grant
- Patent Title: Fusokines involving cytokines with strongly reduced receptor binding affinities
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Application No.: US16103302Application Date: 2018-08-14
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Publication No.: US11358997B2Publication Date: 2022-06-14
- Inventor: Jan Tavernier , Jennyfer Bultinck , Sarah Gerlo , Gilles Uze , Franciane Paul , Yann Bordat
- Applicant: VIB VZW , Universiteit Gent , Centre National De Le Recherche Scientifique , Université De Montpellier , Centre Hospitalier Regional Universitaire de Montpellier
- Applicant Address: BE Ghent; BE Ghent; FR Paris; FR Montpellier; FR Montpellier
- Assignee: VIB VZW,Universiteit Gent,Centre National De Le Recherche Scientifique,Université De Montpellier,Centre Hospitalier Regional Universitaire de Montpellier
- Current Assignee: VIB VZW,Universiteit Gent,Centre National De Le Recherche Scientifique,Université De Montpellier,Centre Hospitalier Regional Universitaire de Montpellier
- Current Assignee Address: BE Ghent; BE Ghent; FR Paris; FR Montpellier; FR Montpellier
- Agency: Morgan, Lewis & Bockius LLP
- Priority: EP13306034 20130718
- Main IPC: C07K14/52
- IPC: C07K14/52 ; C07K14/56 ; A61K38/19 ; A61P37/04 ; C07K14/545 ; C07K14/575 ; A61K38/20 ; C07K14/525
Abstract:
The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced binding affinity to its receptor, or to one of its receptors. Preferably, both cytokines are connected by a linker, preferably a GGS linker. The invention relates further to said fusion protein for use in treatment of diseases.
Public/Granted literature
- US20190010199A1 FUSOKINES INVOLVING CYTOKINES WITH STRONGLY REDUCED RECEPTOR BINDING AFFINITIES Public/Granted day:2019-01-10
Information query
