Invention Grant
- Patent Title: Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway
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Application No.: US16445130Application Date: 2019-06-18
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Publication No.: US11359013B2Publication Date: 2022-06-14
- Inventor: Gordon Freeman , Arlene Sharpe , David M. Dorfman , Rafi Ahmed , Daniel Barber , E. John Wherry
- Applicant: Emory University , Dana-Farber Cancer Institute, Inc. , Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College
- Applicant Address: US GA Atlanta; US MA Boston; US MA Boston; US MA Cambridge
- Assignee: Emory University,Dana-Farber Cancer Institute, Inc.,Brigham and Women's Hospital, Inc.,President and Fellows of Harvard College
- Current Assignee: Emory University,Dana-Farber Cancer Institute, Inc.,Brigham and Women's Hospital, Inc.,President and Fellows of Harvard College
- Current Assignee Address: US GA Atlanta; US MA Boston; US MA Boston; US MA Cambridge
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61P35/00 ; A61K38/17 ; G01N33/50 ; G01N33/574 ; A61K31/713 ; A61K39/39 ; C12N15/113 ; A61K45/06 ; A61K39/00
Abstract:
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
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