- Patent Title: Engineered transaminase polypeptides for industrial biocatalysis
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Application No.: US16615999Application Date: 2018-05-23
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Publication No.: US11359183B2Publication Date: 2022-06-14
- Inventor: Scott J. Novick , Nikki Dellas , Oscar Alvizo , Ravi David Garcia , Charlene Ching , David Entwistle
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- International Application: PCT/US2018/034069 WO 20180523
- International Announcement: WO2018/231462 WO 20181220
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N15/09 ; A61K38/00
Abstract:
The present invention provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The invention also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.
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