A system includes multiple sensors having different, and overlapping, fields of regard and a controller communicatively coupled to sensors. Methods for calibrating the multiple sensors include obtaining data from the sensors, determining optimized transformation parameters for at least one of the sensors, and transforming the data from one sensor projection plane to the other sensor projection plane. The method is an iterative process that uses the metric of mutual information between the data sets, and transformed data sets of the sensors, to determine an optimized set of transformation parameters. The sensors may be a plurality of lidar sensors, a camera and a lidar sensor, or other sets of sensors.