A micro-LED display system is disclosed. The micro-LED display system includes a host, a plurality of row/column drivers and a plurality of μICs. The row/column drivers are coupled to the host through serial interfaces and used to provide a plurality of row clock signals and a plurality of column data signals respectively. The μICs are arranged as a matrix including columns of μICs and rows of μICs receiving the column data signals and the row clock signals respectively. All μICs in the same column of μICs are cascaded in order and all μICs in the same row of μICs are cascaded in order.