An efficient blue-green to orange-red thermally activated delayed fluorescence material, a manufacture method, and an application thereof are provided. This disclosure solves the technical problems in the art by cleverly synthesizing a series of thermally activated delayed fluorescence materials, which have lower singlet-triplet energy difference, high luminous efficiency, and fast reverse intersystem crossing constant, and simultaneously fine-tuning the structure to cover the spectrum from blue-green light to orange-red light. Further, their structures are confirmed by nuclear magnetic resonance and mass spectroscopy, and their photophysical properties are also determined. Therefore, these luminescent thermally activated delayed fluorescence (TADF) materials are applied to light-emitting layer for manufacturing a series of organic light-emitting diodes (OLEDs) having high performance, which have great application prospects and economic value.