An image sensing device includes a first sub-pixel array including a plurality of unit pixels having a first color arranged adjacent to each other, a second sub-pixel array including a plurality of unit pixels having a second color arranged adjacent to the first sub-pixel array in a first direction, a third sub-pixel array including a plurality of unit pixels having a third color arranged adjacent to the second sub-pixel array in a second direction perpendicular to the first direction, and a fourth sub-pixel array including a plurality of unit pixels having the second color arranged adjacent to the first sub-pixel array and the second sub-pixel array in the second direction. The fourth sub-pixel array includes a plurality of phase detection pixels for detecting a phase difference in at least the first direction.