An image sensor includes a pixel array having a plurality pixels arranged in a plurality of pixel clusters coupled to a plurality of column busses, a plurality of voltage supplies coupled to the plurality of pixel clusters, and ping-pong readout circuitry. Pixel clusters in adjacent column busses are supplied with different voltage supplies. The ping-pong readout circuitry includes multiplexing circuitry coupled to the plurality of column busses, and a plurality of analog-to-digital converters coupled to the multiplexing circuitry. The image sensor also includes a controller configured to selectively couple a pixel signal of a pixel cluster to a column bus to an ADC for signal conversion.