A method and a control device for the throughput-optimized production of printed circuit boards on a pick-and-place line is provided. Further provided is a method for the throughput-optimized production of printed circuit boards on a pick-and-place line, wherein: the printed circuit boards are divided into groups known as clusters; each cluster is produced using one set-up; the set-up is realized by changing tables that can be attached to the pick-and-place line, each changing table having at least one feed device for keeping ready stocks of components; a quantity of changing tables needed for each set-up is referred to as a changing table set and an empty changing table set includes changing tables having feed devices that are empty.