The present disclosure relates to the field of display technologies, and provides in embodiments an OLED touch display substrate, a manufacturing method thereof and a corresponding touch display device. Specifically, the OLED touch display substrate comprises: a first electrode layer and a second electrode layer opposite to each other; an organic layer between the first electrode layer and the second electrode layer; a touch layer on a side of the second electrode layer facing away from the organic layer; and a first insulating layer between the touch layer and the second electrode layer. The second electrode layer is a transparent electrode layer.