A semiconductor structure and a fabrication method of the semiconductor structure are provided in the present disclosure. The semiconductor structure includes a substrate, where the substrate includes a shielding region having a first area; a first shielding layer on the substrate, where a first shielding structure is in the first shielding layer of the shielding region, and the first shielding structure has a first density; a second shielding layer on the first shielding layer, where a second shielding structure is in the second shielding layer of the shielding region, and the second shielding structure has a second density which is less than the first density; and an electrical interconnection structure, electrically interconnecting the first shielding structure with the second shielding structure and enabling the first shielding structure grounded.