An air purification device includes an adsorption block, a housing, an introduction port for indoor air, an introduction port for heated air, a return port for indoor air, and a discharge port for used regeneration air. The adsorption block adsorbs purification target substances in indoor air, and is regenerated by dispersing the adsorbed purification target substances by circulating heated air. The housing accommodates the adsorption block therein. The introduction port for indoor air and the introduction port for heated air are provided on one end side of the housing. The return port for indoor air and the discharge port for used regeneration air are provided on the other end side of the housing. An insulating layer is provided between the housing and an outer surface of the adsorption block.