Invention Grant
- Patent Title: Voltage-dependent T-type calcium channel inhibitor
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Application No.: US16479674Application Date: 2018-01-22
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Publication No.: US11370761B2Publication Date: 2022-06-28
- Inventor: Hiroto Tanaka , Isao Ooi , Kohei Hayashida , Toru Ogawa , Atsufumi Kawabata
- Applicant: Nippon Chemiphar Co., Ltd. , Kinki University
- Applicant Address: JP Tokyo; JP Osaka
- Assignee: Nippon Chemiphar Co., Ltd.,Kinki University
- Current Assignee: Nippon Chemiphar Co., Ltd.,Kinki University
- Current Assignee Address: JP Tokyo; JP Osaka
- Agency: Wood Herron & Evans LLP
- Priority: JPJP2017-009755 20170123
- International Application: PCT/JP2018/001790 WO 20180122
- International Announcement: WO2018/135659 WO 20180726
- Main IPC: C07D235/16
- IPC: C07D235/16 ; C07D401/12 ; C07D403/08 ; C07D403/12 ; A61P29/00 ; C07D401/14

Abstract:
A compound represented by General Formula (I), a tautomer, a stereoisomer, or a pharmaceutically acceptable salt of the compound, or a solvate thereof is used as a voltage-dependent T-type calcium channel inhibitor, in the formula, A represents a benzene ring which may have a substituent or the like; B represents a hetero-fused ring consisting of a 5- or 6-membered heteroaryl ring having one to three same or different heteroatoms selected from an oxygen atom, a sulfur atom, and a nitrogen atom, and a carbon atom, as a ring-constituting atom, and a benzene ring, or the like, and the hetero-fused ring may have a substituent, and is bonded to a cyclopropyl group via a carbon atom constituting these rings; R1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like; R2 and R3 may be the same as or different from each other, and each represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like, or R2 and R3 together form CH2CH2 or the like; R4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like; m represents 0, 1, or 2; and n represents 0 or 1.
Public/Granted literature
- US20210323930A1 VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL INHIBITOR Public/Granted day:2021-10-21
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