Invention Grant
![Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one](/docs/US/2022-06-28/US11370795B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
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Application No.: US16615347Application Date: 2018-05-25
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Publication No.: US11370795B2Publication Date: 2022-06-28
- Inventor: Niels Svenstrup , Jun Zhang , Jikui Sun , Yuyin Chen , Jianshe Kong , Rujian Ma , Junhua Zhang , Liang Qin , Huanming Xiao , Jinxu Sun , Xiao Meng , Fenglai Sun , Jingyang Zhu
- Applicant: Imara Inc.
- Applicant Address: US MA Cambridge
- Assignee: Imara Inc.
- Current Assignee: Imara Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Wilson Sonsini Goodrich & Rosati
- International Application: PCT/US2018/034566 WO 20180525
- International Announcement: WO2018/218104 WO 20181129
- Main IPC: C07D487/04
- IPC: C07D487/04
![Process for the synthesis of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one](/abs-image/US/2022/06/28/US11370795B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates a process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2 ylmethyl)pyrrolidin-3-yl)-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one, comprising use of the chiral acid (+)-O,O-Dibenzoyl-D-tartaic acid.
Public/Granted literature
- US20200157108A1 METHODS OF MAKING AND USING PDE9 INHIBITORS Public/Granted day:2020-05-21
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