Invention Grant
- Patent Title: Pyrrolobenzodiazepine conjugates
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Application No.: US16605962Application Date: 2018-04-18
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Publication No.: US11370801B2Publication Date: 2022-06-28
- Inventor: Philip Wilson Howard , Stephen John Gregson
- Applicant: Medimmune Limited
- Applicant Address: GB Cambridge
- Assignee: Medimmune Limited
- Current Assignee: Medimmune Limited
- Current Assignee Address: GB Cambridge
- Agency: Casimir Jones, S.C.
- Agent Lisa Mueller
- Priority: GB1706133 20170418,GB1721337 20171219
- International Application: PCT/EP2018/059846 WO 20180418
- International Announcement: WO2018/192944 WO 20181025
- Main IPC: A61P35/00
- IPC: A61P35/00 ; C07D519/00 ; A61K47/68

Abstract:
A compound of formula I and salts and solvates thereof, wherein: R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR′, nitro, Me3Sn and halo; where R and R′ are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR′, nitro, Me3Sn and halo; R″ is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, NRN2 (where RN2 is H or C1-4 alkyl), and/or aromatic rings, e.g. benzene or pyridine; Y and Y′ are selected from O, S, or NH; R6, R7, R9 are selected from the same groups as R6, R7 and R9 respectively; R11b is selected from OH, ORA, where RA is C1-4 alkyl; and RL is a linker for connection to a cell binding agent.
Information query
IPC分类:
A | 人类生活必需 |
A61 | 医学或兽医学;卫生学 |
A61P | 化合物或药物制剂的特定治疗活性 |
A61P35/00 | 抗肿瘤药 |