Invention Grant
- Patent Title: Extracellular heme production method using metabolically engineered microorganism
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Application No.: US16483430Application Date: 2018-12-12
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Publication No.: US11371068B2Publication Date: 2022-06-28
- Inventor: Sang Yup Lee , Xin Rui Zhao , Kyeong Rok Choi
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Hultquist, PLLC
- Agent Steven J. Hultquist
- Priority: KR10-2017-0170185 20171212,KR10-2018-0158452 20181210
- International Application: PCT/KR2018/015748 WO 20181212
- International Announcement: WO2019/117612 WO 20190620
- Main IPC: C12N1/22
- IPC: C12N1/22 ; C12P17/18 ; C12N9/02 ; C12N9/10 ; C12N9/88 ; C12N9/90 ; C12N9/00 ; C12N15/67 ; C12P13/00

Abstract:
The present invention relates to a microorganism variant having the ability to extracellularly produce heme, and more particularly to a metabolically engineered microorganism variant having the ability to extracellularly produce heme and a method of producing heme using the same. According to the present invention, heme, an organometallic compound which is increasingly used as a health food or food supplement for the treatment of porphyria, can be extracellularly secreted and produced in high yield using the microorganism variant, but not conventional chemical synthesis or enzymatic synthesis.
Public/Granted literature
- US20190382817A1 EXTRACELLULAR HEME PRODUCTION METHOD USING METABOLICALLY ENGINEERED MICROORGANISM Public/Granted day:2019-12-19
Information query
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