Systems and methods for simulation of ambient light based on generated imagery are disclosed herein. Such a system can include a simulation sled, a simulation display that can display generated imagery viewable from the simulation sled, an ambient light simulator that can selectively illuminate portions of the simulation sled, and a processor. The simulation sled can include a plurality of user controls. The processor can: control the simulation display to generate imagery; identify an effect of the generated imagery on the simulation sled; and control the ambient light simulator to selectively illuminate at least portions of the simulation sled according to the identified effect of the simulated light source.