The present technology relates to an imaging device, a method of driving the same, and an electronic instrument capable of improving functions by using high-speed readout in a period shorter than the output cycle of an image. An imaging device includes a pixel array unit in which pixels are arranged in a matrix, and a control unit that controls image readout by the pixel array unit. The control unit causes the pixel array unit to perform image readout twice or more within a cycle of outputting one image to the outside. The present technology can be applied to an imaging device or the like including a memory area, for example.