The disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. The UE receives first information, receives a first signaling and transmits a first radio signal. The first information is used for determining a first air interface resource and a second air interface resource, and the first signaling includes scheduling information of the first radio signal; in instances in which the first radio signal is related to the first air interface resource, the scheduling information of the first radio signal is codebook-based; in instances in which the first radio signal is related to the second air interface resource, the scheduling information of the first radio signal is non-codebook-based. The above method has following benefits: when multiple TRPs serve one UE simultaneously, each TRP can select an optimal precoding mode depending on its own actual condition.