A self-propelled wrapping machine movable around a load to wrap the load with a film of plastic material, comprises a wrapping apparatus, which includes a supporting base, a column fixed thereto and an unwinding unit slidably supported by the column and suitable to supply the film unwound from a reel; and an automatic guided vehicle movable and arranged to be reversibly and automatically coupled to the supporting base in an assembled condition of the self-propelled wrapping machine to support and move the wrapping apparatus around the load and enable to wrap the load with the film.