Invention Grant
- Patent Title: Ribonucleic acid purification
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Application No.: US14776864Application Date: 2014-03-13
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Publication No.: US11377470B2Publication Date: 2022-07-05
- Inventor: William Joseph Issa , John Grant Aunins , Stephane Bancel
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- International Application: PCT/US2014/026842 WO 20140313
- International Announcement: WO2014/152031 WO 20140925
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H1/06 ; C08B37/00 ; C12Q1/6806 ; C12N15/10

Abstract:
Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2′deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.
Public/Granted literature
- US20160024140A1 RIBONUCLEIC ACID PURIFICATION Public/Granted day:2016-01-28
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