Invention Grant
- Patent Title: Ras inhibitory peptides and uses thereof
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Application No.: US16696027Application Date: 2019-11-26
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Publication No.: US11377476B2Publication Date: 2022-07-05
- Inventor: Gregory L. Verdine , John Hanney McGee
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Hogan Lovells US LLP
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/22 ; C07K7/06 ; C07K7/08 ; C07K14/00 ; C07K14/575 ; C07K14/47 ; C07K14/82 ; C12N15/10 ; A61K38/00
Abstract:
The present invention provides peptides comprising a sequence of X-6X-5X-4X-3X-2X-1X1PX3X4PX6X7PGX10X11AX13X14X15X16LX18X19X20X21X22X23LX25X26YLX29X30X31X32 (SEQ ID NO: 13) wherein the amino acids X−6, X−5, X−4, X−3, X−2, X−1, X1, X3, X4, X6, X7, X10, X11, X13, X14, X15, X16, X18, X19, X20, X21, X22, X25, X26, X29, X30, X31, and X32 are as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology.
Public/Granted literature
- US20200239533A1 RAS INHIBITORY PEPTIDES AND USES THEREOF Public/Granted day:2020-07-30
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