- Patent Title: Method for treating cancer using disulfide-linked trimeric 4-1BBL
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Application No.: US16803126Application Date: 2020-02-27
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Publication No.: US11377490B2Publication Date: 2022-07-05
- Inventor: Peng Liang
- Applicant: Sichuan Clover Biopharmaceuticals, Inc.
- Applicant Address: CN Chengdu
- Assignee: Sichuan Clover Biopharmaceuticals, Inc.
- Current Assignee: Sichuan Clover Biopharmaceuticals, Inc.
- Current Assignee Address: CN Chengdu
- Agent Yuqin Jin
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K16/24 ; A61K9/00 ; C07K14/52 ; C07K16/28 ; A61K38/19 ; A61P35/04 ; A61K38/00 ; A61K39/00
Abstract:
Compositions of TNF family of cytokines in covalently linked trimeric forms are disclosed. The resulting fusion proteins are secreted as disulfide bond-linked homotrimers, which are more stable in structure and therapeutically more efficacious than their native counterparts.
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