Invention Grant
- Patent Title: System and methods for deriving gene signature biomarkers of response to PD-1 antagonists
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Application No.: US15533769Application Date: 2015-12-08
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Publication No.: US11377693B2Publication Date: 2022-07-05
- Inventor: Mark D. Ayers , Andrey Loboda , Jared K. Lunceford , Terrill K. McClanahan , Erin E. Murphy , Michael Nebozhyn
- Applicant: Mark D. Ayers , Andrey Loboda , Jared K. Lunceford , Terrill K. McClanahan , Erin E. Murphy , Michael Nebozhyn , Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Pennington; US MA Canton; US UT Washington; US CA Sunnyvale; US CA Redwood City; US PA Colmar; US NJ Rahway
- Assignee: Mark D. Ayers,Andrey Loboda,Jared K. Lunceford,Terrill K. McClanahan,Erin E. Murphy,Michael Nebozhyn,Merck Sharp & Dohme Corp.
- Current Assignee: Mark D. Ayers,Andrey Loboda,Jared K. Lunceford,Terrill K. McClanahan,Erin E. Murphy,Michael Nebozhyn,Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Pennington; US MA Canton; US UT Washington; US CA Sunnyvale; US CA Redwood City; US PA Colmar; US NJ Rahway
- Agent Sarah L. Hooson; Alysia A. Finnegan
- International Application: PCT/US2015/064445 WO 20151208
- International Announcement: WO2016/094377 WO 20160616
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; G16B20/00 ; G16B30/00 ; G16B40/00 ; C07K16/28 ; C12Q1/68 ; G16B40/30 ; G16B20/20 ; G16H50/30 ; A61K39/00
Abstract:
A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed.
Public/Granted literature
- US20180327848A1 SYSTEM AND METHODS FOR DERIVING GENE SIGNATURE BIOMARKERS OF RESPONSE TO PD-1 ANTAGONISTS Public/Granted day:2018-11-15
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