The preset disclosure provides a display control method, a timing controller IC and a display device. The method includes: acquiring a preset grayscale voltage of a target pixel unit and a backlight brightness of a backlight region corresponding to the target pixel unit, in a current output display frame; outputting a first grayscale voltage to the target pixel unit if the backlight brightness of the corresponding backlight region is less than or equal to a first preset brightness value; outputting a second grayscale voltage to the target pixel unit if the backlight brightness of the corresponding backlight region is greater than the first preset brightness value; wherein the second grayscale voltage is greater than the first grayscale voltage, and both the second grayscale voltage and the first grayscale voltage are greater than the preset grayscale voltage.