A radiation resistant high-entropy alloy is provided, having an FCC structure, defined by general formula of FeCoNiVMoTixCry, where 0.05≤x≤0.2, 0.05≤y≤0.3, x and y are molar ratios. The radiation resistant high-entropy alloy has excellent irradiation resistance and is subject to radiation hardening saturation at high temperature (600° C.) in a condition of a high dose (1-3×1016 ions/cm2) of helium ion irradiation. A lattice constant of the high-entropy alloy decreases abnormally after irradiation. The high-entropy alloy has a radiation resistance far higher than that of a conventional alloy and has an excellent plasticity and specific strength. In an as-cast condition and at room temperature, a tensile break strength of the high-entropy alloy is higher than 580 MPa, an engineering strain (a tensile elongation) of the high-entropy alloy is greater than 30%.