Systems and methods for dynamic maximum transmission unit determination are disclosed. For example, one or more triggering events may be detected to initiate determining whether to adjust transmission unit sizing for data transmission between devices. Received signal strength indicator (RSSI) values may be exchanged between the devices and those RSSI values may be utilized to determine a strength of a communication signal between devices. When the RSSI values are low, the communication signal strength may be weak and the devices may adjust the transmission unit size to be larger. In other examples when the RSSI values are high, the communication signal strength may be strong and the devices may adjust the transmission unit size to be smaller.