In some examples, a device initiates an acknowledgement storm detection process in response to failover of a network connection from a first input/output (I/O) module to a second I/O module. The acknowledgement storm detection process includes determining whether desynchronization between a received packet and a sent packet satisfies a criterion, and in response to determining that the desynchronization between the received packet and the sent packet satisfies the criterion, initiate an action to recover from the desynchronization.