Presented systems and methods facilitate efficient and effective communication interference mitigation. In one embodiment, a method comprises: configuring a payload portion of information in a normal transmission sub-channel; puncturing information in a punctured sub-channel; adjusting a mitigation sub-channel use to mitigate interference associated with the punctured sub-channel; and transmitting the information in the normal transmission sub-channel, the punctured sub-channel, and the mitigation sub-channel.