Invention Grant
- Patent Title: Roundabout (Robo) receptor inhibitors and uses thereof
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Application No.: US16641263Application Date: 2018-08-24
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Publication No.: US11406682B2Publication Date: 2022-08-09
- Inventor: Yarden Opatowsky , Reut Barak-Fucks , Julia Guez-Haddad , Galit Yom-Tov
- Applicant: Bar-Ilan University
- Applicant Address: IL Ramat-Gan
- Assignee: Bar-Ilan University
- Current Assignee: Bar-Ilan University
- Current Assignee Address: IL Ramat-Gan
- International Application: PCT/IL2018/050936 WO 20180824
- International Announcement: WO2019/038772 WO 20190228
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/00 ; A61K38/10 ; C07K9/00
Abstract:
The present invention, in some embodiments thereof, relates to inhibitory compositions binding to the ectodomain of a Roundabout (Robo) receptor and to the use of same for downregulating Robo-mediated signaling. In particular, the present invention provides moieties that bind to and prevent dimerization of an Ig-like Robo receptor ectodomain, thereby inhibiting Robo receptor activity.
Information query
