Invention Grant
- Patent Title: Methods for the treatment of tissue lesions with CCR2 agonists
-
Application No.: US16098689Application Date: 2017-05-02
-
Publication No.: US11406686B2Publication Date: 2022-08-09
- Inventor: Selim Aractingi , Mathieu Catela , Dany Nassar , Zhe Wang
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , SORBONNE UNIVERSITE , UNIVERSITE PARIS DESCARTES , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
- Applicant Address: FR Paris; FR Paris; FR Paris; FR Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),SORBONNE UNIVERSITE,UNIVERSITE PARIS DESCARTES,ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),SORBONNE UNIVERSITE,UNIVERSITE PARIS DESCARTES,ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
- Current Assignee Address: FR Paris; FR Paris; FR Paris; FR Paris
- Agency: WCF IP
- Priority: EP16305512 20160503
- International Application: PCT/EP2017/060351 WO 20170502
- International Announcement: WO2017/191100 WO 20171109
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61P19/02 ; A61P17/02 ; A61K45/06 ; C07K16/28 ; C12N15/115 ; G01N33/50 ; A61K47/68 ; A61K39/395 ; C07K14/52 ; A61K39/00
Abstract:
The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call “fetal myeloid progenitor cells” (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.
Public/Granted literature
- US20210268068A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TISSUE LESIONS Public/Granted day:2021-09-02
Information query
IPC分类:
