An object trajectory prediction system of a vehicle includes: one or more sensors to generate sensory data corresponding to one or more objects within a range of the vehicle; one or more processors; and memory connected to the one or more processors and having instructions that, when executed by the one or more processors, cause the one or more processors to: identify a first person of interest (POI) from the sensory data; estimate a 3-dimensional (3D) pose of the first POI from the sensory data; calculate a trajectory of the first POI according to at least the 3D pose of the first POI; and determine a navigational path of the vehicle according to the trajectory of the first POI.