Invention Grant
- Patent Title: Compounds and their use as selective inhibitors of caspase-2
-
Application No.: US16650629Application Date: 2018-09-26
-
Publication No.: US11407741B2Publication Date: 2022-08-09
- Inventor: Etienne Jacotot , Elodie Bosc
- Applicant: UNIVERSITÉ DE PARIS , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: FR Paris; FR Paris; FR Paris; FR Paris
- Assignee: UNIVERSITÉ DE PARIS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,SORBONNE UNIVERSITE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: UNIVERSITÉ DE PARIS,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,SORBONNE UNIVERSITE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Paris; FR Paris; FR Paris; FR Paris
- Agency: Pearne & Gordon LLP
- Priority: EP17306270 20170926
- International Application: PCT/EP2018/076178 WO 20180926
- International Announcement: WO2019/068538 WO 20190411
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D207/16 ; C07D401/12 ; C07D417/14
Abstract:
The present invention relates to a compound of formula (I): wherein P1, P3, P4 and P5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.
Public/Granted literature
- US20200317647A1 NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 Public/Granted day:2020-10-08
Information query
