Invention Grant
- Patent Title: Heterocycle compounds as Tyro3, Axl and MerTK (TAM) family of receptor tyrosine kinase inhibitors
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Application No.: US16958721Application Date: 2018-12-26
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Publication No.: US11407757B2Publication Date: 2022-08-09
- Inventor: Shih-Chieh Yen , Chu-Bin Liao , Hui-Chen Wang , Po-Ting Chen , Yu-Chih Pan , Tsung-Hui Li , Bo-Rong Chen , Shian-Yi Chiou
- Applicant: Development Center for Biotechnology
- Applicant Address: TW Taipei
- Assignee: Development Center for Biotechnology
- Current Assignee: Development Center for Biotechnology
- Current Assignee Address: TW Taipei
- Agency: Liang Legal Group, PLLC
- International Application: PCT/US2018/067532 WO 20181226
- International Announcement: WO2019/133629 WO 20190704
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61P35/00

Abstract:
Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R1, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.
Public/Granted literature
- US20210009597A1 HETEROCYCLE COMPOUNDS AS TYRO3, AXL AND MERTK (TAM) FAMILY OF RECEPTOR TYROSINE KINASE INHIBITORS Public/Granted day:2021-01-14
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