A variety of amphiphobic porous materials are provided. The materials can include a variety of porous frameworks that have an outer surface functionalized by a plurality of perfluoroalkyl moieties. By careful selection of appropriate perfluoralkyl moieties, hydrophobic properties can be imparted to the exterior surface of the porous materials without significantly impacting the wetting properties of the porous interior. This can be used to create a variety of highly amphiphobic porous materials. Methods of making and using the amphiphobic porous materials are also provided.