Invention Grant
- Patent Title: Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
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Application No.: US17059251Application Date: 2019-05-30
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Publication No.: US11407771B2Publication Date: 2022-08-09
- Inventor: Michael J. Holtzman , Arthur G. Romero , Benjamin J. Gerovac , Zhenfu Han , Shamus P. Keeler , Kangyun Wu
- Applicant: Washington University
- Applicant Address: US MO Saint Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO Saint Louis
- Agency: Stinson LLP
- International Application: PCT/US2019/034751 WO 20190530
- International Announcement: WO2019/232275 WO 20191205
- Main IPC: C07D417/06
- IPC: C07D417/06 ; C07F7/08 ; C07D213/75
Abstract:
Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
Public/Granted literature
- US20210214378A1 MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, METHODS OF MAKING, AND METHODS OF USE THEREOF Public/Granted day:2021-07-15
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