- Patent Title: Compositions and methods of chimeric autoantibody receptor T cells
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Application No.: US16390638Application Date: 2019-04-22
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Publication No.: US11407803B2Publication Date: 2022-08-09
- Inventor: Aimee S. Payne , Christoph T. Ellebrecht , Vijay Bhoj , Michael C. Milone
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K16/28 ; A61K39/00 ; A61K48/00
Abstract:
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.
Public/Granted literature
- US20190315829A1 COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS Public/Granted day:2019-10-17
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