Invention Grant
- Patent Title: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
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Application No.: US17347863Application Date: 2021-06-15
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Publication No.: US11408001B1Publication Date: 2022-08-09
- Inventor: Kevin Fitzgerald , William Querbes , James Butler , Stephanie Williams , Abigail Liebow , Gregory Hinkle , Martin A. Maier , Stuart Milstein , Satyanarayana Kuchimanchi , Muthiah Manoharan
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; A61P3/04 ; A61P43/00 ; A61P13/12 ; A61P1/18 ; A61P3/10 ; A61P9/12 ; A61P15/08 ; A61P9/10 ; A61P1/16 ; A61P3/06
Abstract:
The present invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the apolipoprotein C3 (APOC3) gene, and methods of using such RNAi agents to inhibit expression of APOC3 and methods of treating subjects having an APOC3 associated disorder, e.g., hypertriglyceridemia.
Information query
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