Invention Grant
- Patent Title: N-cadherin and FGFR1 and/or FGFR4 for use in predicting the response of patients to a lung cancer treatment and method and kit based on said use
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Application No.: US16630021Application Date: 2018-07-13
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Publication No.: US11408038B2Publication Date: 2022-08-09
- Inventor: Luis Paz-Ares Rodríguez , Álvaro Quintanal Villalonga , Irene Ferrer Sánchez , Sonia Molina Pinelo , Amancio Carnero Moya
- Applicant: FUNDACIÓN DE INVESTIGACIÓN HOSPITAL 12 DE OCTUBRE , SERVICIO ANDALUZ DE SALUD , CONSE-JO SUPERIOR DE INVESTIGACIONES CIENTÍFI-CAS (CSIC)
- Applicant Address: ES Madrid; ES Seville; ES Seville
- Assignee: FUNDACIÓN DE INVESTIGACIÓN HOSPITAL 12 DE OCTUBRE,SERVICIO ANDALUZ DE SALUD,CONSE-JO SUPERIOR DE INVESTIGACIONES CIENTÍFI-CAS (CSIC)
- Current Assignee: FUNDACIÓN DE INVESTIGACIÓN HOSPITAL 12 DE OCTUBRE,SERVICIO ANDALUZ DE SALUD,CONSE-JO SUPERIOR DE INVESTIGACIONES CIENTÍFI-CAS (CSIC)
- Current Assignee Address: ES Madrid; ES Seville; ES Seville
- Agency: Casimir Jones, S.C.
- Agent Tristan A. Fuierer
- Priority: ESESP201730929 20170713
- International Application: PCT/ES2018/070501 WO 20180713
- International Announcement: WO2019/016422 WO 20190124
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; G01N33/574
Abstract:
The present invention describes a method for predicting the response of a subject suffering from lung cancer to treatment with FGFR inhibitors. The relationship between the expression of the biomarkers and the treatment response allows the subjects to be classified as responsive or unresponsive to the treatment, which facilitates the therapeutic decision-making of the attending clinician. The present invention also describes the biomarkers N-cadherin, FGFR1 and FGFR4, how to analyse them and how to interpret the results obtained, in order to administer FGFR inhibitors only to the subjects that are responsive to the treatment, thereby optimising the same, which allows the unresponsive subjects to be treated with alternative therapies to the FGFR inhibitors.
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