A method for operating an injection system of an internal combustion engine, including: providing the injection system includes a high pressure accumulator; regulating a high pressure in the high pressure accumulator in a normal operation by way actuating a low pressure-side suction throttle; regulating the high pressure in a first operating mode of safety operation by way of actuating at least one high pressure-side pressure control valve; carrying out a switchover from the normal operation into the first operating mode of safety operation if the high pressure reaches or exceeds a first limit pressure value; and carrying out a switchover from the first operating mode of safety operation into the normal operation if, starting from above a setpoint pressure value, the high pressure reaches or undershoots the setpoint pressure value, which is lower than the first limit pressure value.