An evaporative cooling system includes an evaporative cooler liquid-to-air membrane energy exchanger (LAMEE), a first liquid-to-air heat exchanger (LAHE), and a cooling fluid circuit. The evaporative cooler LAMEE is disposed within a scavenger air plenum that is configured to channel a scavenger air stream. The first LAHE is disposed within a process air plenum that is configured to channel a process air stream. The cooling fluid circuit is configured to circulate an evaporative cooling fluid between the evaporative cooler LAMEE and the first LAHE. The evaporative cooler LAMEE is configured to utilize the scavenger air stream to evaporatively cool the cooling fluid. The first LAHE is configured to receive the cooling fluid from the evaporative cooler LAMEE and to allow the cooling fluid to absorb heat from the process air stream to cool the process air stream.