A computer-implemented method of reducing noise and artifacts in medical images is provided. The method includes receiving a series of medical images along a first dimension, wherein the signals in the medical images having a higher correlation in the first dimension than the noise and the artifacts in the medical images. The method further includes, for each of a plurality of pixels in the medical images, deriving a series of data points along the first dimension based on the series of medical images, inputting the series of data points into a neural network model, and outputting the component of signals in the series of data points. The neural network model is configured to separate a component of signals from a component of noise and artifacts in the series of data points. The method further includes generating a series of corrected medical images based on the outputted component of signals.