Systems, methods and apparatus of intelligent optimization of caching operations in a data storage device. For example, the data storage device can include: one or more storage media components; a controller configured to store data into and retrieve data from the one or more storage media components; a cache memory configured to cache data that is stored in the one or more storage media components; and an artificial neural network configured to receive, as input and as a function of time, operating parameters indicative a data access pattern. The artificial neural network generates, based on the input, a prediction to determine an optimized set of cache configuration parameters; and cache operations of the cache memory are configured according to the optimized set of cache configuration parameters determined based on the prediction.