Invention Grant
- Patent Title: Mesothelin chimeric antigen receptor (CAR) and antibody against PD-L1 inhibitor for combined use in anticancer therapy
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Application No.: US16065387Application Date: 2016-12-21
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Publication No.: US11413340B2Publication Date: 2022-08-16
- Inventor: Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe
- Applicant: Novartis AG , The Trustees of the University of Pennsylvania , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Applicant Address: CH Basel; US PA Philadelphia; US MA Boston; US MA Cambridge
- Assignee: Novartis AG,The Trustees of the University of Pennsylvania,DANA-FARBER CANCER INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: Novartis AG,The Trustees of the University of Pennsylvania,DANA-FARBER CANCER INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee Address: CH Basel; US PA Philadelphia; US MA Boston; US MA Cambridge
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- International Application: PCT/US2016/067957 WO 20161221
- International Announcement: WO2017/112741 WO 20170629
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/00 ; A61P35/00 ; A61K45/06
Abstract:
Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.
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