Invention Grant
![Substituted pyrido[4,3-b]indoles and azepino[4,5-b]indoles as inhibitors of cGAS](/docs/US/2022-08-16/US11414422B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrido[4,3-b]indoles and azepino[4,5-b]indoles as inhibitors of cGAS
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Application No.: US16967656Application Date: 2019-02-05
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Publication No.: US11414422B2Publication Date: 2022-08-16
- Inventor: Lodoe Lama , Thomas Tuschl , Daisuke Tomita , Dinshaw Patel , J. Fraser Glickman , Taku Kamei , Michael Miller , Yasutomi Asano , Rei Okamoto , Shogo Hashizume , Jumpei Aida , Toshihiro Imaeda , Mayako Michino , Takanobu Kuroita
- Applicant: The Rockefeller University , Memorial Sloan-Kettering Cancer Center
- Applicant Address: US NY New York; US NY New York
- Assignee: The Rockefeller University,Memorial Sloan-Kettering Cancer Center
- Current Assignee: The Rockefeller University,Memorial Sloan-Kettering Cancer Center
- Current Assignee Address: US NY New York; US NY New York
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- International Application: PCT/US2019/016673 WO 20190205
- International Announcement: WO2019/153002 WO 20190808
- Main IPC: A61K31/407
- IPC: A61K31/407 ; C07D487/04 ; C07D471/04
![Substituted pyrido[4,3-b]indoles and azepino[4,5-b]indoles as inhibitors of cGAS](/abs-image/US/2022/08/16/US11414422B2/abs.jpg.150x150.jpg)
Abstract:
1-(3,4-Dihydro-1H-pyrido[4, 3-b]indol-2(5H)-yl)-2-hydroxyethanones are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
Public/Granted literature
- US20210155625A1 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4, 3-b]INDOLE INHIBITORS OF cGAS FOR TREATING AUTOINFLAMMATORY DISEASES Public/Granted day:2021-05-27
Information query
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