Invention Grant
- Patent Title: Fusion protein comprising transcription modulation domain of p65 and protein transduction domain, and uses thereof
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Application No.: US16443098Application Date: 2019-06-17
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Publication No.: US11414467B2Publication Date: 2022-08-16
- Inventor: Sang-Kyou Lee , Sung-Dong Park
- Applicant: Good T Cells, Inc.
- Applicant Address: KR Seoul
- Assignee: Good T Cells, Inc.
- Current Assignee: Good T Cells, Inc.
- Current Assignee Address: KR Seoul
- Agency: DLA Piper LLP US
- Priority: KR10-2015-0142144 20151012
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K38/00 ; C07K14/47
Abstract:
The present invention relates to a novel fusion protein comprising the transcription modulation domain of the transcription factor NF-κB subunit p65 and a protein transduction domain and to the use thereof. The fusion protein of the present invention has the effects of inhibiting the transcription of NF-κB and IL-2 by competitive inhibition and inhibiting the LPS-induced secretion of inflammatory cytokines and also inhibiting the production of IL-2, IFN-γ, IL-4, IL-17A and IL-10 in splenocytes, and thus is effectively used as a composition for the prevention or treatment of a disease related to NF-κB overactivity.
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