Invention Grant
- Patent Title: Mutant and genetically modified Bacillus cells and methods thereof for increased protein production
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Application No.: US16957217Application Date: 2018-12-12
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Publication No.: US11414643B2Publication Date: 2022-08-16
- Inventor: Shannon Del Chase , Carol Marie Fioresi , Ryan L. Frisch , Helen Olivia Masson , Anita Van Kimmenade
- Applicant: DANISCO US INC.
- Applicant Address: US CA Palo Alto
- Assignee: DANISCO US INC.
- Current Assignee: DANISCO US INC.
- Current Assignee Address: US CA Palo Alto
- International Application: PCT/US2018/065150 WO 20181212
- International Announcement: WO2019/135868 WO 20190711
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C07K14/32 ; C12N15/75 ; C12P21/02

Abstract:
The instant disclosure is generally related to novel Bacillus sp. mutants capable of producing increased amounts of industrially relevant proteins of interest. Certain embodiments of the disclosure are related to modified Bacillus sp. cells comprising an introduced polynucleotide encoding a variant GlcT protein. Other embodiments are related to methods and compositions for producing endogenous and/or heterologous proteins of interest in the modified Bacillus sp. (daughter) cells, whereas certain other embodiments are directed to nucleic acid sequences, particularly polynucleotide open reading frame (ORF) sequences, vectors thereof and DNA expression constructs thereof, encoding variant GlcT proteins of the disclosure.
Information query
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