The invention provides a physiological parameter sensing system (50) and method in which physiological information indicative of at least one physiological parameter is derived. The approach of the invention is based on constructing multiple pulse signals from different weighted combinations of at least two detection signals, derived from detected electromagnetic radiation directed onto or through a subjects skin region. The weightings are based on different of a set of various blood volume pulse vectors. A quality indication value is derived for each generated pulse signal, where this is based on a derived relationship between an obtained heart rate signal for the patient and the pulse signal. The blood volume pulse vector resulting in the pulse signal having the highest quality indicator value and/or from the derived pulse signal itself is used to derive the physiological parameter information.