Invention Grant
- Patent Title: Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases
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Application No.: US16852360Application Date: 2020-04-17
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Publication No.: US11419861B2Publication Date: 2022-08-23
- Inventor: Philip Chamberlain , Brian E. Cathers , Antonia Lopez-Girona
- Applicant: Celgene Corporation
- Applicant Address: US NJ Summit
- Assignee: Celgene Corporation
- Current Assignee: Celgene Corporation
- Current Assignee Address: US NJ Summit
- Agency: Jones Day
- Main IPC: A61K31/454
- IPC: A61K31/454 ; A61K31/517 ; C12Q1/37 ; G16B15/30 ; G16B15/00
Abstract:
Provided herein are compositions, therapeutic methods, screening methods, computational methods and biomarkers based upon the elucidation of the interaction among cereblon, its substrates and certain compounds or agents, including small molecules, peptides, and proteins.
Public/Granted literature
- US20210000813A1 COMPOSITIONS AND METHODS FOR INDUCING CONFORMATIONAL CHANGES IN CEREBLON AND OTHER E3 UBIQUITIN LIGASES Public/Granted day:2021-01-07
Information query
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