Invention Grant
- Patent Title: Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases
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Application No.: US17686385Application Date: 2022-03-03
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Publication No.: US11420936B2Publication Date: 2022-08-23
- Inventor: Jiping Fu , Yan Lou , Yigang He
- Applicant: NIKANG THERAPEUTICS, INC.
- Applicant Address: US DE Wilmington
- Assignee: NIKANG THERAPEUTICS, INC.
- Current Assignee: NIKANG THERAPEUTICS, INC.
- Current Assignee Address: US DE Wilmington
- Agency: Squire Patton Boggs (US) LLP
- Main IPC: C07C255/54
- IPC: C07C255/54 ; A61P35/00
Abstract:
The present disclosure is directed certain Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and their use in the treatment of diseases mediated by HIF-2α such as cancer. Also provided is the use of HIF-2α inhibitors in combination with a poly (ADP-ribose) polymerase (PARP) inhibitor. In particular, the present disclosure is directed to methods for the treatment of cancers using a HIF-2α inhibitor in combination with a PARP inhibitor and pharmaceutical compositions comprising the same.
Public/Granted literature
- US20220185771A1 HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASES Public/Granted day:2022-06-16
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